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Author

G. McKay-Corkum

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Sep 2026

Abstract A022: Cell state-directed integrated functional genomics reveals TAB1 as a central controller of the neuroblastoma chemoresistant mesenchymal cell state

Resistance to conventional chemotherapies is a major cause of cancer patient relapse and subsequent death. The fundamental biological properties of tumor cells are not only driven by acquired genetic mutations, but also by aberrant epigenetic regulation leading to corresponding changes in the expressed transcriptome....

G. McKay-Corkum, Noha A. M. Shendy, S. Nance et al. · 0 citations
Open access Aug 2026

Therapeutic NAMPT inhibition reveals a targetable metabolic vulnerability in neuroblastoma

NB is identified as a highly NAMPT inhibitor-sensitive pediatric solid tumor and NAMPT-dependent NAD + biosynthesis as a targetable metabolic vulnerability in this disease is established.

Sophia Varriano, Amy Yu, Abantika Chakraborty et al. · 0 citations

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