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Open access Sep 2026

HIF1α-KLF4 signaling dictates extra-erythrocyte expression of hemoglobin conferring sorafenib resistance in hepatocellular carcinoma

Cancer cells must deal with excessive reactive oxygen species (ROS) to survive severe hypoxia and anticancer therapy; however, anti-ROS mechanisms other than the well-known NFE2L2/NRF2 signaling pathway are poorly recognized. Here, we report a ROS scavenging mechanism mediated by HIF1α-KLF4-induced hemoglobin extraeryt...

Bo Zhang, Fei-Chang Liu, Xin-Yue Gao et al. · 0 citations
Review Open access Sep 2026

Hantavirus: biology, immune responses, and pathogenesis

This review synthesizes the recent research on hantavirus biology, cellular entry mechanisms, and epidemiological characteristics, and highlights that viral immune evasion and subsequent uncontrolled host immune responses act as the core pathogenic drivers.

Yu-Fang Shi, Mauro Piacentini, A. Zumla et al. · 0 citations
Open access Jul 2026

SERPINH1 expression represents a reliable biomarker of human breast cancer aggressiveness.

These findings identify SERPINH1 as a marker of ECM-driven tumour aggressiveness and stromal reprogramming in breast cancer and emerges as a promising prognostic biomarker and a tractable therapeutic target in breast cancer.

M. Scimeca, V. Palumbo, F. Servadei et al. · 0 citations

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