Lenacapavir resistance surveillance in full-length HIV-1 proviral DNA and circulating RNA: Major RAMs are rare and absent in intact proviral DNA.
BACKGROUND Lenacapavir (LEN) has made the HIV-1 capsid relevant for resistance surveillance, but p24 variation within gag remains less well characterized than the resistance landscape of pol. This limits the clinical interpretation of capsid variation, particularly when detected in biologically distinct compartments su...