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Review Sep 2026

Primary cilia: master conductors of cellular communication in development and disease.

Emerging evidence indicates that cell-type-specific and temporally dynamic ciliary signatures determine signalling competence and disease susceptibility, and defining these signatures and the mechanisms that regulate their plasticity could lead to new therapeutic opportunities for ciliopathies and other cilia-associate...

O. K. Thomsen, Gaia Pigino, L. B. Pedersen et al. · 0 citations
Open access Aug 2026

Rho/ROCK-dependent actomyosin contractility drives extracellular vesicle release from the cilium

It is demonstrated that the release of extracellular vesicles from the cilium relies on actomyosin contractility supported by non-muscle myosin IIA acting downstream of the RhoA-ROCK signaling pathway, and that the cilia of these cells release EVs independently of de novo actin polymerization.

William J. Spencer, Margaux J. Kreitman, Nicholas F. Schneider et al. · 0 citations

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