G. Pontone

World Journal of Nephrology

Adverse Remodeling and Fibrosis Predict Outcomes in Excessive Trabeculation of the Left Ventricle: A Multiparametric CMR Risk Score.

BACKGROUND Excessive trabeculation of the left ventricle (ETLV) is a heterogeneous and controversial phenotype that overlaps with both physiological remodeling and cardiomyopathy. OBJECTIVES This study sought to develop and validate a cardiac magnetic resonance (CMR)-based model to predict major adverse cardiovascula...

Early aortic valve replacement for asymptomatic severe aortic stenosis: an updated systematic review and meta-analysis.

BACKGROUND The optimal timing of intervention in asymptomatic severe aortic stenosis remains debated. This updated meta-analysis evaluates the comparative effects of early surgical or transcatheter aortic valve replacement (AVR) versus conservative management by incorporating recent long-term randomized evidence. MET...

Radiation burden of contemporary diagnostic pathways for chronic coronary syndromes: an ancillary analysis of the international EURECA Imaging Registry.

Cumulative radiation exposure in CCS varies substantially according to diagnostic strategy and practice patterns, whereas non-invasive, guideline-adopting pathways are associated with lower radiation burden, whereas ICA-first approaches lead to higher exposure.

Real-world implementation of ESC guidelines in chronic coronary syndromes: Insights from the EURECA registry with a focus on Italian practice.

GA was higher in IC as compared with the NIC but still suboptimal, especially in Italian-southern region, and non-GA was mainly driven by exercise-ECG and ICA as first test use.

CCTA characterization of coronary atherosclerosis diffuseness and focality using FFR-CT and plaque burden: results from the PRECISE trial.

INTRODUCTION Coronary artery disease (CAD) on coronary computed tomography angiography (CCTA) is typically assessed using a dichotomous ≥ 50 % stenosis threshold. However, CAD diffuseness may also influence patient management and outcomes. The PRECISE trial provides high quality data to examine these relationships. M...

Left ventricular outflow tract obstruction and myocardial edema burden in Takotsubo syndrome: acute and long-term outcomes-insights from the EVOLUTION registry.

LVOTO in patients with TTS, is independently associated with the extent of myocardial edema, and is more frequently observed in patients who experience in-hospital complications, though the limited number of events and wide confidence interval warrant cautious interpretation.

Mortality reduction with implanted defibrillator for primary prevention of sudden death after Myocardial Infarction: temporal trends in the PROFID study.

In this analysis including a large cohort of post-myocardial infarction patients with reduced LVEF, the estimated mortality reduction associated with primary prevention ICD implantation progressively decreased over time.

Artificial Intelligence-enhanced cardiac MRI reporting: expert validation and patient-centered outcomes.

ChatGPT-4o improved the accessibility of CMR reports and patients' perceived comprehension and satisfaction while preserving expert-validated report accuracy, and large-language-model outputs should be deployed as adjunctive, physician-supervised decision support rather than autonomously.