Author

G. Ramm

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Open access Oct 2026

A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair.

There are no currently approved therapies that promote new myelin formation after myelin damage, which can, in part, be attributed to a lack of reliable systems that can reproducibly model these processes. Here we engineered a human iPSC-derived spheroid model enriched with mature, myelinating oligodendrocytes and func...

Shwathy Ramesan, Joel Mason, Sandeep S. Kumar et al. · Nature Neuroscience · 0 citations

Open access Jul 2026

Bioenergetic profiling of fresh human kidney tissue reveals compensatory metabolic adaptation and intrinsic mitochondrial dysfunction in diabetes

This study provides the first direct tissue-level functional evidence that mitochondrial metabolism is reprogrammed in the human kidney in diabetes before measurable kidney dysfunction develops, and defines an early bioenergetic signature characterised by tissue hypermetabolism despite impaired mitochondria-specific re...

C. Granata, A. Laskowski, V. Thallas-Bonke et al. · bioRxiv · 0 citations