G. Rani

GAUCHER`S DISEASE: DIAGNOSIS, ENZYME REPLACEMENT THERAPY, AND PHARMACEUTICAL FORMULATIONS IN TREATMENT– A COMPREHENSIVE REVIEW

Gaucher's disease (GD) is the most common lysosomal storage disorder caused by mutations in the GBA1 gene, resulting in deficiency of the enzyme β-glucocerebrosidase. This leads to the accumulation of glucosylceramide within macrophages, causing progressive involvement of the liver, spleen, bone marrow, and, in severe...

Design and in Vitro Neuroprotective Evaluation of Pyrimidine-Based Compounds for Alzheimer’s Therapy