Open access
Sep 2026
Peripheral Immune Alterations and T Cell Clonal Dynamics Across the Parkinson's Disease Spectrum
The role of peripheral immunity in Parkinson's disease (PD) remains incompletely understood. Here, we performed paired single-cell RNA sequencing (scRNA-seq) and T-cell receptor (TCR) profiling of 630k peripheral blood mononuclear cells (PBMCs) from 168 donors spanning idiopathic and genetic PD, prodromal PD, and healt...
M. Rosen, J. O. Narcis Majos, D. Mattei et al.
· medRxiv · 0 citations