Open access
Sep 2026
Antibody-TLR3 agonist-conjugates program the tumor microenvironment and induce immune responses leading to tumor regression in experimental EGFRvIII-positive glioma.
It is revealed that RICIA is internalized by glioma cells via EGFRvIII-mediated endocytosis and induces a TLR3-dependent type I interferon response.
Alexander Hagstotz, Isabell Schau, Michael Seifert et al.
· Biomedicine & pharmacotherap... · 0 citations