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G. Severino

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Open access Sep 2026

683. Genomic foundations of precision treatment: polygenic risk and pleiotropy in predicting therapeutic response

Abstract Background Major depressive disorder (MDD) is the most common mental disorder and is associated with substantial functional impairment, socioeconomic costs and reduced quality of life. One third of patients presents treatment-resistant depression (TRD), a major clinical challenge that highly contributes to the...

C. Pisanu, Y. Xiong, D. Congiu et al. · 0 citations

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