G. Srivastava

Identification of Novel Inhibitors of JEV RdRp as Potent Antiviral Drugs: Targeting NS5-NS3 Protein Interaction

Targeting EZH2 and EGFR Therapeutic Vulnerabilities of TNBC with a Single Chemical Entity Confers Preclinical Treatment Advantage.

Globally, Triple-Negative Breast Cancer (TNBC) has huge unmet medical need as it has limited targeted therapeutic options. However, it has well-known therapeutic vulnerabilities for selective inhibition of pathways like EGFR, m-TOR, PARP, EZH2, PD1-PDL1 etc. Analysis of publicly available databases clearly suggest that...

Integrated machine learning and structural bioinformatics guided identification of novel molecular scaffolds as renin inhibitors.

This study identified 4 promising hits - HTS00804, HTS05294, BTB13902, and RJC01726 with diverse piperazine and piperidine-substituted scaffolds for renin inhibition, and can be explored as a starting scaffold for further structural optimization through medicinal chemistry efforts to design next-generation direct renin...