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G. Stein-O'Brien

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Open access Sep 2026

36 Clear Cell Renal Cell Carcinoma Consensus Transcriptomic Programs Reveal Converging Trajectories Towards Aggressive Disease

Abstract Background Clear cell renal cell carcinoma (ccRCC) is characterized by a branching genomic architecture in which biallelic VHL inactivation is followed by divergence into PBRM1- or BAP1-mutant lineages, with subsequent acquisition of additional alterations contributing to progression and aggressive behavior. H...

Roy Elias, Vivek Nimgaonkar, B. Xie et al. · 0 citations

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