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Author

G. Superti-Furga

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Open access Sep 2026

High-resolution structures of human NHE6 and NHE9 elucidate endosomal ion and lipid interactions

Endosomal NHE6 (SLC9A6) and NHE9 (SLC9A9) transporters are essential for maintaining pH homeostasis within endosomes and their dysfunction has been linked to neurological and neurodegenerative disorders. NHE6 and NHE9 are widely considered to function as electroneutral exchangers that couple the export of protons to th...

Jesper S. Hansen, Ashley C. W. Pike, Gamma Chi et al. · 0 citations
Open access Jul 2026

The topology of transmembrane protein-protein interaction interfaces is encoded in their physicochemical features

It is concluded that PPI interface characteristics harbor substantial information about TM interface topology and provide a framework for the study and design of membrane protein interaction interfaces.

Lisa Allmesberger-Riegler, Fabian Frommelt, Brianda L. Santini et al. · 0 citations

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