Author

G. Tofaris

3 papers indexed here

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Oct 2026

Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis.

Microglia are the primary immune cells of the brain, but their role in Parkinson's disease is not fully understood. Chronic microglial activation is toxic to neurons, but in the early stages of pathology, microglia also exert beneficial functions. We used induced pluripotent stem cell (iPSC)-derived coculture models to...

Hung-Ju Chueh, Antigoni Katsikoudi, Ana Aragón-González et al. · Science Translational Medici... · 0 citations

Open access Sep 2026

Electronic profiling of neuronal extracellular vesicles enables early prediction of Parkinson’s disease

Misfolded alpha-Synuclein (α-Syn) accumulation is the defining molecular pathology of Parkinson’s disease (PD), yet blood-based assays remain challenged by the high background of peripheral α-Syn originating mainly from red blood cells. Neuronal extracellular vesicles (EVs) circulating in blood offer a biologically enr...

Tian-Rui Chang, Cheng Jiang, Shi-Jun Yan et al. · Science Advances · 0 citations

Open access Aug 2026

α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease

The primary mechanism and subcellular localisation of α-synuclein toxicity in Parkinson’s disease pathogenesis remain unknown. We spatially and temporally resolved proteomic and transcriptomic changes in human iPSC-derived dopaminergic neurons with increasing burden of pathological α-synuclein. We found that misfolded...

Chor Lai Lam, N. Gatford, Ana Aragón-González et al. · Nature Communications · 0 citations