G. V. van Wezel

Application of a microdroplet array platform for high-throughput analysis of growth and natural product biosynthesis of Streptomyces

Streptomycetes are prolific producers of natural products, accounting for the majority of clinically used antibiotics and other bioactive compounds. Their remarkable biosynthetic diversity and ecological versatility are reflected in the large number of biosynthetic gene clusters (BGCs) within their genomes. However...

Plant-associated Streptomyces detoxify the mycotoxin fusaric acid by amino acid conjugation

Total Synthesis of Paenitracin B and Analogues with Enhanced Antibacterial Activity.

The total synthesis of paenitracin B is reported, enabling definitive stereochemical validation of the previously proposed structure and delivering quantities of material suitable for more extensive antibacterial testing.