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Author

G. Vassal

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2 papers indexed here

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Oct 2026

Clinically actionable genetic findings by exome sequencing performed for therapeutic purposes in children with very-high risk cancer included the MAPPYACTS study.

INTRODUCTION Next-generation sequencing performed for therapeutic decision-making in pediatric cancers provides an opportunity to identify germline variants associated with hereditary cancer predisposition and other actionable inherited conditions. METHODS Germline whole-exome sequencing (WES) was performed within th...

Tiphaine Adam-de-Beaumais, Yahia Adnani, L. Guerrini-Rousseau et al. · 0 citations
Sep 2026

Abstract B012: In vivo Mini screen to assess the Antitumor Effect of Carboxyamidotriazole orotate (CTO) and temozolomide (TMZ) in Monotherapy in Three ITCC-P4’s High-grade Glioma (HGG) Pediatric Patient Derived Xenograft (PDX) Tumor Models

The aim of this study was to evaluate in vivo antitumor activity of CTO, a novel, oral small molecule orotate formulation of carboxyamidotriazole (CAI). The antiproliferative and antimetastatic properties of CTO are driven by the inhibition of calcium influx through receptor-operated channels. By disrupting calci...

R. Karmali, Romina Walter, J. Gojo et al. · 0 citations

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