G. Worrell

Moving beyond spike detection: High frequency-driven masking improves seizure onset zone localization in intracranial electroencephalography.

OBJECTIVE Interictal epileptiform spikes (IESs) are widely used biomarkers of epileptogenic tissue in presurgical epilepsy evaluation. However, their reliability for seizure onset zone (SOZ) localization in high-density intracranial electroencephalography (iEEG) remains inconsistent. It is underexplored whether this va...

Electrical perturbation reveals a directional architecture for communication across human visual streams

Pulvinar and anterior nucleus of the thalamus dual-network neuromodulation for complex epilepsies.

Combined four-lead ANT/PUL DBS appears safe and effective for patients with drug-resistant posterior quadrant and temporal lobe epilepsies and dual-network neuromodulation may provide greater flexibility to individually optimize neuromodulation for complex seizure networks.

A Translational Platform for Brain-Computer Interfaces and Adaptive Neuromodulation: Technical Characterization, Long-Term Validation, and Implementation of the CorTec Brain Interchange–BCI2000 Ecosystem

Objective Adaptive neuromodulation systems and implantable brain-computer interfaces (BCIs) are promising therapies for neurological and psychiatric disorders. However, their broader translation into research and clinical practice remains limited by technological complexity, restricted access to implantable research pl...