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Open access Sep 2026

SAMSN1 restricts Japanese encephalitis virus replication by recruiting TRIM21 to degrade viral proteins and activate the interferon pathway

Japanese encephalitis virus (JEV), a zoonotic mosquito-transmitted flavivirus, induces human encephalitis and swine reproductive diseases. No antiviral drugs or treatments exist for flavivirus infections, which cause severe symptoms. Even though some host proteins can suppress flavivirus proliferation, the virus can in...

Chen Wang, Wen-Zhen Qin, Xing-Ya Wang et al. · 0 citations
Open access Sep 2026

GPNMB promotes double-membrane vesicle accumulation and facilitates structural protein transport during PEDV infection

ABSTRACT Porcine epidemic diarrhea virus (PEDV) causes substantial economic losses in the swine industry globally. Host factors regulating the intracellular replication of PEDV, particularly early RNA synthesis and structural protein production, are not well understood, limiting antiviral strategies. We report that gly...

Qin Li, Qiang Wei, Aiping Wang et al. · 0 citations

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