G. Zengin

Chemical profiling, biological evaluation, and QSAR-informed metabolite prioritization of Hypericum ekerii: a first report on antioxidant, enzyme inhibitory, and cytotoxic activities

Hypericum ekerii Yüce and Aytaç, first described in 2017, remains poorly characterized in terms of its phytochemical composition and biological properties. This study investigated aerial-part extracts of H. ekerii prepared with ethyl acetate, acetone, 70% acetone–water, and water. The hydroacetone extract showed the hi...

Storage Temperature-Dependent Changes in Physiology, Bioactive Compounds, Essential Oils, and Antibacterial Activity of Fresh Sage (Salvia officinalis)

: Enhancing the quality and extending the storage of fresh herbs is becoming more and more popular, as their high perishability is often associated with suboptimal storage environments. This study examined the impacts of temperature (2, 6, and 20 ◦ C) on the quality attributes of fresh Salvia officinalis (sage) after p...

Beyond the fruit: phenolic composition, cytotoxicity, antioxidant, and multi-enzyme inhibitory activity of twig and leaf extracts from four understudied Turkish Rosa species

The phytochemical profile and multi-target bioactivity of four Turkish Rosa species, R. canina, R. hemisphaerica, R. horrida, and R. pulverulenta, were evaluated across vegetative organs (twigs and leaves) and three solvent polarities (ethyl acetate (EA), methanol (MeOH), water), in total 24 extracts. Untargeted Ultra-...

First comprehensive in vitro and in silico investigations of the antidiabetic activity of Cladostephus spongiosus (Cladostephaceae): from marine ecosystem to biological application

Antimicrobial potential of Miscanthus × giganteus extracts: linking in vitro and in silico activity with in situ efficacy in milk

Miscanthus × giganteus is a high-biomass, low-input crop whose potential as a source of antimicrobial compounds remains insufficiently explored. This study investigated the phytochemical composition, antioxidant and antimicrobial properties of methanolic (MeOH) and dichloromethane (DCM) extracts obtained from roots, rh...

Decoding the Immuno-Oncology-Microbiome axis: Breakthroughs in mechanisms, technologies, and clinical applications

The Immuno-Oncology-Microbiome (IOM) axis is a tripartite regulatory system involving microbiota, immune cells, and tumors, which critically modulates cancer progression and therapy response. This systematic review synthesizes key advances from 2022 to 2025, illustrating the field’s evolution from macro-associations to...

Synthesis, Biological Evaluation, Molecular Docking and DFT Studies of Electronically Tuned Benzylidene-Based Schiff Bases

Inspired by the medicinally relevant stilbene scaffold, a series of six electronically tuned benzylidene-based Schiff base derivatives were designed, synthesized, and characterized by FT-IR, 1H NMR, 13C NMR, and ESI-MS analyses. The biological properties of the synthesized compounds were investigated through antioxidan...

Metabolomic characterization and multi-target biological activities of Saponaria pumila and Suaeda confusa: integrating in vitro and in silico approaches

In the present study, several extracts (ethyl acetate, methanol, and water) of Saponaria pumila and Suaeda confusa were used to characterize and identify their biological activities. The chemical characterization was performed using HPLC-ESI-Orbitrap-MS/MS. The total phenolic and flavonoid contents were determined by t...

Allium ursinum L. from the apennine flora: a phytoalimurgic resource for modulating gut inflammation

Allium ursinum L. is a perennial herbaceous plant widely distributed across Europe and Asia. Its leaves are traditionally consumed as food and used in folk medicine, particularly for gastrointestinal well-being. Despite its phytochemical and ethnopharmacological similarity to Allium sativum, whose gastrointestinal prot...

Salvia limbata extracts and essential oil as a novel source of bioactive agents: metabolomic fingerprint, in vitro, in silico and network pharmacological perspectives

The genus Salvia has received considerable attention and has been studied extensively owing to its rich polyphenolic content. In the present study, Salvia limbata essential oil (EO) and extracts from its aerial parts and roots were used to examine the chemical profile and biological activities. The chemical profiles of...

Logic-gated nanoregulators: A paradigm shift from drug delivery to pre-programmed multi-target immunotherapy.

This review traces the evolution of nanomedicine from a passive drug delivery vehicle to a therapeutic program encoded in a physical structure, and examines the design constraints that will determine whether the next generation of cancer nanomedicines fulfills its clinical promise.

Human biomarker navigator

This review offers the initial comprehensive elucidation of the biomarker interaction networks across diverse systems, organs, and diseases, and delineates the operational framework for establishing a “biomarker navigation system”.