Microglia are essential immune cells of the brain parenchyma which are responsible for maintaining homeostasis and responding to brain injury. When activated, they induce immune signaling and become phagocytic. In the context of neurodegenerative diseases, they exhibit both pro- and anti-inflammatory properties. Human...
Hoi-Tong Wong, C. Gleason, Andrew Boylan et al.· bioRxiv· 0 citations
This high-resolution atlas of genetic regulation of gene expression in the human prefrontal cortex provides insight into the cell type-specific regulatory architecture of the human brain, and offers novel mechanistic targets for understanding the genetic basis of neuropsychiatric and neurodegenerative diseases.
B. Zeng, Hui Yang, Prashant N. M. et al.· Nature Genetics· 2 citations
A single-nucleus transcriptomic atlas spanning the human lifespan is used to show that the dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selective molecular reactivation in la...
Hui Yang, Tereza Clarence, Madeline R. Scott et al.· Nature· 4 citations
These findings provide a cell-type-resolved and ancestry-aware atlas of genetically regulated expression in the human prefrontal cortex and illustrate how single-nucleus transcriptomics can sharpen gene discovery and therapeutic target prioritization for complex brain disorders.
S. Venkatesh, Roman Kosoy, Zhen-Yi Wu et al.· Nature· 7 citations
A population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex provides a perspective of the transcriptomic landscape in neurodegenerative and neuropsychiatric disorders, and offers potential targets for therapeutic intervention.
Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse et al.· Nature· 6 citations
A personalized functional genomics atlas for Alzheimer’s disease that uses knowledge-guided graph neural networks to analyze donor-level functional genomics, identify disease subpopulations and trajectories, and link genetic variants to gene regulation is summarized.
P. Chandrashekar, S. Alatkar, Noah Cohen Kalafut et al.· Nature Communications· 1 citation
The complexity of Alzheimer's disease (AD) manifests in diverse clinical phenotypes, including cognitive impairment and neuropsychiatric symptoms. However, the etiology of these phenotypes remains elusive. To address this, the PsychAD project generated a population-level single-nucleus RNA sequencing dataset comprising...
Chen-Feng He, Athan Z. Li, Kalpana Hanthanan Arachchilage et al.· Nature Medicine· 1 citation
It is shown that a disease-associated microglial subtype, characterized by elevated GPNMB expression and enriched for polygenic AD risk, expands with AD pathology and shows increased phagocytic activity, and MITF is identified as an upstream regulator required to maintain this microglial state.
Donghoon Lee, James M. Vicari, Christian Porras et al.· Nature Genetics· 1 citation
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