Chronic Chrysin, but Not Diazepam, Induces Anxiolytic-like Effects Without Behavioral Tolerance
Background: Chrysin (5-7-dihydroxyflavone) exerts anxiolytic-like effects via the GABAA/benzodiazepine receptor complex after acute administration, similar to diazepam. Chronic diazepam treatment produces pharmacological tolerance, likely due to structural receptor modification. Whether chronic chrysin treatment also p...