Gabriel S. Longo

Protein adsorption on charge regulating silica nanoparticles: Understanding the effects of pH, ionic strength, and curvature.

Protein adsorption onto silica nanoparticles is governed by a complex interplay between electrostatics, acid-base chemistry, and short-range interactions. In this work, we develop a molecular theory that explicitly incorporates charge regulation of both silica silanols and protein titratable residues, together with res...