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Gabrielle Martinez

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Open access Aug 2026

Studying the effect of conserved tyrosine phosphorylation within SH2 domains

Specific tyrosine residues within the PTPN11-N, LYN, and SYK-C SH2 domains are studied, finding that the PTPN11 N-terminal site (Y63) modulates the specificity, reducing binding of physiologically relevant substrates.

Gabrielle Martinez, Mindolay Fike, Madhuri Sosale et al. · 0 citations

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