Sep 2026
H3K27M drives OPC stemness and intrathecal therapeutic vulnerability in brainstem glioma organoids.
Brainstem gliomas, particularly H3K27M-mutant diffuse midline gliomas (DMGs), lack effective therapies owing to anatomic inaccessibility, intact blood-brain barrier, and treatment resistance. Conventional models have low establishment rates and fail to preserve the native tumor microenvironment, limiting translational...
Lu-Yang Xie, Zhuan-Xin Jiang, Hang Zhou et al.
· Cell Stem Cell · 1 citation