Electrospun core–shell nanofibres embedding drug nanocrystals for long-acting mucosal delivery
NAR-NCs exhibited a mean hydrodynamic diameter of ∼280 nm, narrow size distribution, high stability over 10 days, and a 3.6-fold increase in saturation solubility compared to raw NAR, supporting their suitability as a mucoadhesive, mechanically robust and biocompatible platform for oral mucositis treatment.