Gaiqian Song

Discovery of pentagalloylglucose as a dual GSTP1/ P-gp inhibitor uncovered by integrated computational and experimental approaches.

Taxol remains a cornerstone therapy for non-small cell lung cancer, however, the development of acquired resistance continues to pose a significant clinical hurdle. Glutathione S-transferase P1 (GSTP1) and P-glycoprotein (P-gp) have been identified as key mediators of this multi-drug resistance phenotype. Consequently,...