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Author

Gajanan Sathe

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Open access Sep 2026

Targeted dephosphorylation of Tau at the endogenous level promotes its association with microtubules

Hyperphosphorylation of Tau is a contributory factor for Tauopathies, which constitute a spectrum of neurodegenerative disorders including Alzheimer’s disease (AD). Inhibitors of Tau kinases or activators of the Tau phosphatase PP2A to reverse Tau hyperphosphorylation have shown limited therapeutic promise, due primari...

Gajanan Sathe, Francesco Berterame, Tyrell Cartwright et al. · 0 citations
Open access Aug 2026

Targeted degradation of alpha-synuclein impedes PFF-induced aggregation

The Affinity-directed PROtein Missile system is employed and targeted degradation of α-synuclein impedes the pre-formed fibril (PFF)-induced aggregation of α-synuclein in primary neurons derived from rats expressing human α-synuclein.

Bill Carton, Géraldine Gelders, Gajanan Sathe et al. · 0 citations
Open access Jul 2026

Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC

A molecular glue-stabilizer and PROTAC strategies are combined to enable ubiquitination of the 14-3-3/estrogen receptor α complex, revealing cooperative linker-dependent activity and a structural basis for targeted E3 ligase recruitment.

Carlo J. A. Verhoef, Charlotte Crowe, M. Nakasone et al. · 0 citations

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