Gamze Altıntaş Kazar

In Silico Screening of Helianthus tuberosus L. Phytochemicals as Candidate 5-HT3A Receptor Ligands for Irritable Bowel Syndrome: Molecular Docking, Conformational Flexibility, and ADME/Toxicity Profiling

Dysregulated serotonergic signaling, including altered 5-HT₃ receptor activity, contributes to the pathophysiology of diarrhea-predominant irritable bowel syndrome (IBS-D), yet the most clinically established 5-HT₃A antagonist, alosetron, carries serious safety concerns including ischemic colitis and severe constipatio...