Author

Gang Chen

2 papers indexed here

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Aug 2026

Rhein alleviates lethal renal ischemia-reperfusion injury via inhibition of NLRP3 inflammasomes by targeting PPARγ.

It is demonstrated here that rhein can potently protect against lethal renal IRI in mice by targeting and enhancing the expression of PPARγ, thereby inhibiting the activation of the NLRP3 inflammasome.

Cheng Fu, Tianyi Hu, Xiangli Zhao et al. · Biochemical Pharmacology · 0 citations

Open access Sep 2026

Evaluation of primate anti-pig xenoreactive immune responses using immortalized aortic endothelial cells from genetically modified pigs

Porcine vascular endothelial cells are primary targets of humoral and cellular immune responses in pig-to-primate organ xenotransplantation. Although porcine aortic endothelial cells (PAECs) are widely used to evaluate primate anti-pig immune responses, their limited proliferative capacity poses a significant obstacle...

Man Zhang, Hao Feng, Jun-Long Wu et al. · Frontiers in Immunology · 0 citations