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Author

Gang Chen

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2 papers indexed here

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Aug 2026

Mechanism of SGLT2 inhibitors in improving immune imbalance in diabetic mice with sepsis via regulating macrophage M2 polarization through the APOC1/HMGB1/TLR4 axis.

This study aimed to investigate the mechanism by which the sodium-glucose cotransporter-2 (SGLT2) inhibitor dapagliflozin improves immune imbalance in sepsis with diabetes, focusing on its regulation of macrophage M2 polarization through the APOC1/HMGB1/TLR4 axis. A mouse model of type 2 diabetes was established throug...

Ting-Ting You, Huo-Bao Yang, Gang Chen · 0 citations
Review Aug 2026

Extracellular vesicles in inflammatory bowel disease: from immune regulation and barrier repair to precise transformation.

Extracellular vesicles (EVs) have been shown to be key regulators of intestinal homeostasis and inflammatory responses, offering new insights into the pathogenesis of inflammatory bowel disease (IBD) and the development of targeted therapeutic strategies. EVs in the intestine can be secreted by intestinal epithelial ce...

Yiyi Lv, Qian Yang, Xi-Xi Cai et al. · 0 citations

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