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Open access Aug 2026

Structural basis of GSDME pore formation and its regulation by S-palmitoylation

Pyroptosis is defined as gasdermin-mediated lytic programmed cell death. Gasdermin E (GSDME), a substrate of the apoptotic caspase-3, can convert apoptosis into pyroptosis, with critical roles in antitumor immunity and chemotherapy-induced tissue damage. Despite its importance, the structural mechanism of GSDME pore fo...

Gang Du, Julian F. Ehrmann, Judy Lieberman et al. · 0 citations

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