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Oct 2026

CRISPR screen reveals FTO-mediated m6A modification of ATF3 as protective in ischaemic stroke.

RNA modifications, especially N6-methyladenosine (m6A), have emerged as pivotal regulators of gene expression in neurological disorders, yet their roles in ischaemic stroke remain unclear. Here, we performed a CRISPR-Cas9 loss-of-function screen targeting 118 RNA modification-related genes in neuronal cells subjected t...

Jiang-Tao Yu, Xiao-Lu Zhu, Qian-Yu Lu et al. · 0 citations
Review Open access Sep 2026

Urine-derived induced pluripotent stem cells for non-invasive diagnosis of bladder cancer

Bladder cancer (BLCA) remains one of the most prevalent and costly malignancies worldwide, largely owing to its high recurrence rate and the invasive nature of conventional surveillance modalities. Induced pluripotent stem cell (iPSC) technology offers a new framework for disease modeling and, potentially, precision di...

Yuan Zhu, J. Shang, Xin Zhang et al. · 0 citations

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