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Aug 2026

DNA Nanoruler-Assisted Linearization for Long-Chain Nucleic Acids Analysis.

Long-chain nucleic acids (LCNAs) are increasingly important as diagnostic biomarkers, yet their quantitative detection is often hindered by compact conformations that limit probe accessibility. Here, we report a DNA nanoruler-assisted linearization strategy that mechanically regulates LCNA conformation by employing a r...

Xi Yu, Shi-Lan Fu, Gang Liu et al. · 0 citations
Open access Aug 2026

Plasma titration provides a physical ruler for cross-platform proteomics

Plasma proteomics is expanding across platforms and cohorts, and integrating these data for AI demands comparability at the protein level, not merely concordant associations1,2. Affinity and MS platforms use distinct probes (antibodies, aptamers, or peptides) and signal readouts, yielding contradictory cross-platform r...

Yaqing Liu, Haiyan Wang, Yutong Zhang et al. · 0 citations

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