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Author

Gangasani Jagadeesh Kumar

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Aug 2026

Post-translational chemical modification of E3 ligase for efficient target protein degradation.

This work reports the first ligand-directed chemical strategy that converts transient PROTAC-mediated ternary complex formation into binary target recognition via post-translational chemical modification of an E3 ligase, and believes it could provide a platform for next-generation targeted protein degraders to overcome the current limitation of PROTAC approach.

Eunbin Park, Jinjoo Jung, Gangasani Jagadeesh Kumar et al. · 0 citations