Ganji Sri Ranjani

Molecular mechanisms behind the functional (non)redundancy of CK1 paralogs in the Wnt pathway

The findings resolve prior contradictions by clarifying context-dependent CK1 roles, identifying mechanistic determinants navigating CK1α and CK1ε to different substrates, and defining the limitations of these affinity-based subcellular distributions that become apparent especially in the physical absence of the physio...