Open access
Jul 2026
Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors
The first pooled, genome-wide CRISPR-Cas9 knockout (KO) screen with authentic HBV infection is performed and these results are integrated with two orthogonal pooled screens to identify host factors to expand the catalog of HBV host factors and provide a scalable framework for host target discovery.
C. A. Freije, Georgios Dangas, Antonis Athanasiadis et al.
· bioRxiv · 0 citations