Open access
Aug 2026
Development of Covalent Inhibitors of Chikungunya Virus nsP2 Cysteine Protease Enabled by Direct-to-Biology Synthesis and Screening
A rapid drug development platform that integrates covalent docking with direct-to-biology (D2B) synthesis and screening to identify nsP2 inhibitors is presented, which establish a streamlined strategy for covalent inhibitor development and provide promising leads for CHIKV antiviral development.
Zheng-Jun Cai, Kan Li, Sainetra Sridhar et al.
· Journal of Medicinal Chemist... · 1 citation