Gaurav Nandagawli

A Computational Framework for Erythropoietin Protein Synthesis and Optimization: Integrating Protein Language Models, AlphaFold3 Structural Prediction, and Bayesian Optimization

- Erythropoietin (EPO) is a 166-residue, four-helix-bundle glycoprotein hormone that regulates erythropoiesis and remains one of the most clinically significant recombinant biopharmaceuticals in use today. Despite four decades of structural and pharmacological characterization, the rational engineering of EPO analogues...