Gautam Sighvi

Novel tetrazole annulation on benzopyridodiazepine derivatives as inhibitor of tropomyosin kinase B (TrkB): rational design, synthesis, biological evaluation, SAR, and in silico studies

Four new series of tetrazole annulated benzopyridodiazepine derivatives are synthesized, especially 14h, which shows significant inhibition of TrkB in neuroblastoma cells, indicating that the tetrazole annulated benzopyridodiazepine is an interesting molecule for exploration in the management of cancer and neurological...