Neuroimmune Interactions in Chronic Pain and Neuroinflammation: Peripheral Nerve Injury, Neuroimmune Mechanisms, and Therapeutic Recovery
The pathogenesis of chronic pain includes persistent neuroimmune interactions that contribute to both peripheral and central pain sensitization. Tissue injury and peripheral nerve injury activate immune and glial pathways through various cytokines, chemokines, complement, damage-associated molecular patterns (DAMPs), a...