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Author

Gavin P. Reynolds

2 papers indexed here

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Open access Sep 2026

Gamma-Oryzanol Solid Dispersion Attenuates Dexamethasone-Induced Depressive-like Behaviors in Rats Associated with Calbindin-1 and Calcium Signaling

Depression is associated with dysfunction of the hypothalamic–pituitary–adrenal axis, neurotransmitter imbalance, and calcium signaling deficits. Although gamma-oryzanol (GO) has shown antidepressant effects, its underlying molecular mechanism remains elusive, while its poor aqueous solubility limits its nutraceutical...

Siripaporn Kesyou, W. Tiyaboonchai, Jureepon Roboon et al. · 0 citations
Open access Sep 2026

Association between BDNF methylation and expression of the NLRP3 inflammasome in the brain is disrupted in Alzheimer’s disease

Activation of the NLRP3 inflammasome pathway and dysfunction of brain-derived neurotrophic factor (BDNF) are both implicated in the pathogenesis of Alzheimer’s disease (AD). While in vitro and in vivo models support these mechanisms, there is little research investigating their relationship in human brain tissue, and w...

Hao Tang, H. Fachim, M. Harte et al. · 0 citations

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