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Author

GE Serrano

2 papers indexed here

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Open access Aug 2026

Increased Binding of [18F]Nifene, a PET Imaging Probe for α4β2* Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Parkinson's Disease Brain

Non‐motor symptoms in Parkinson's disease (PD) may be influenced by the α4β2* subtype of nicotinic acetylcholine receptors (nAChRs) present in the hippocampus (HP) and subiculum (SUB). To continue efforts in positron emission tomography (PET) diagnostics for PD, autoradiographic [18F]nifene binding to α4β2* nAChR was q...

J. Mukherjee, Fariha Karim, Allyson Ngo et al. · 0 citations
Open access Aug 2026

Elevated DYRK1A in Primary Tauopathies and Therapeutic Targeting with the Brain-Penetrant Inhibitor DYR533

An association between elevated DYRK1A and disease severity in human primary tauopathies is established and pharmacological inhibition of DYRK1A with DYR533 reduces pathological tau phosphorylation and neuroinflammatory signaling in vivo.

R. Velazquez, Samantha K. Bartholomew, W. Winslow et al. · 0 citations

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