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Open access Sep 2026

Interleukin-24 Induces Inflammatory Chemokine and Cytokine Responses in Fibroblast-Enriched Synovial Cells from Patients with Knee Osteoarthritis

Background: Interleukin-24 (IL-24) is expressed in synovial myofibroblasts and has been associated with pain severity in female patients with knee osteoarthritis (OA). However, the direct effects of IL-24 on inflammatory responses in synovial fibroblasts and the signaling pathways involved remain unclear. This study in...

Yui Uekusa, Kentaro Uchida, Makoto Itakura et al. · 0 citations
Aug 2026

Deep Learning Versus LASSO-Based Machine Learning for 1-Year Survival After Surgery for Spinal Metastases: A JASA Multicenter Prospective Cohort Analysis.

STUDY DESIGN Multicenter prospective cohort study; secondary analysis. OBJECTIVE To evaluate predictors associated with 1-year survival after surgery for spinal metastases by comparing a comprehensive 50-variable deep learning (DL) model with a previously published 5-variable LASSO-based machine learning (ML) model a...

S. Ito, Hiroaki Nakashima, N. Segi et al. · 0 citations

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