An improved NKG2A engager is reported to selectively inhibit NKG2A⁺ NK cells while avoiding activation of NKG2C⁺ subsets, thereby overcoming a key limitation of the natural ligand HLA-E.
Tingxi Guo, Kaya Epstein, M. Hoover et al.· EMBO Molecular Medicine· 0 citations
Analysis of transcriptomic and flow cytometry analyses and a novel hypoimmune approach improves allogeneic cell persistence by preventing T, B, and NK cell mediated rejection support EngTregs as a potent, stable, and versatile cell therapy platform for autoimmune, inflammatory, and ischemic diseases.
P. Zarin, Gene I. Uenishi, Martina Sassone-Corsi et al.· Journal of Immunology· 0 citations
GNTI-932 is a novel, hypoimmune, antigen-specific, off-the-shelf immunotherapy for restoring tolerance in IBD, designed to be scalable and affordable for widespread use.
Martina Sassone-Corsi, J. Yam, Abigail Doherty et al.· Journal of Immunology· 0 citations
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