Author

Geng-Yan Luo

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Open access Sep 2026

Library strategies differentially shape microbial, functional, and host signals in clinical metagenomic sequencing

ABSTRACT Metagenomic next-generation sequencing (mNGS) is increasingly used in infectious disease diagnostics, yet how library preparation shapes the microbial, functional, and host signals recovered from clinical samples remains poorly defined. Here, we performed a within-sample parallel comparison of three mNGS libra...

Geng-Yan Luo, Jin Zhao, Lin-Lin Xie et al. · mSystems · 0 citations

Review Open access Sep 2026

Multi-kingdom microbial diversity and interaction landscapes in mosquitoes revealed by 5,163 individual meta-transcriptomes

Mosquitoes are pathogen vectors embedded within diverse microbial ecosystems. However, the nature and interactions among their multi-kingdom microbiome remain poorly understood. We conducted a nationwide single-mosquito meta-transcriptomic survey of 5,163 mosquitoes representing 100 species across China, integrating vi...

Qin-yu Gou, Wei-Chen Wu, Pei-Bo Shi et al. · bioRxiv · 0 citations