Regnase-1 is an essential RNase that suppresses immune cell activation by targeting the mRNA of pro-inflammatory cytokines such as interleukin 6 (IL-6). Although genetic inhibition of Regnase-1 activity in CD8+ T cells has been shown to enhance antitumor immunity, no molecular inhibitors of Regnase-1 have been report...
Arthur Millius, C. Yew, Yuko Misumi et al.· NAR Molecular Medicine· 0 citations
Structural and functional characterization of a novel CA, θ-CA3, from the diatom Phaeodactylum tricornutum, elucidating its physiological role and catalytic mechanism are reported, offering a new perspective on the molecular basis of carbon fixation in diatoms.
Hiroto Negoro, Atsuki Ohsawa, Ginga Shimakawa et al.· The FEBS Journal· 0 citations
Three-dimensional covalent organic frameworks (3D COFs) are promising crystalline porous materials, but the elucidation of their structure remains challenging, particularly for those featuring spiroborate linkages. Herein, we report the synthesis of a 3D crystalline COF with nbo topology, constructed from a rigid squar...
Soshi Hirota, Haruki Sugiyama, N. Hirata et al.· Science Advances· 1 citation
A new PubChem Portal that enables interactive exploration of compound‐protein interactions and enhances access to biological insights through integrated visualization and analysis is developed.
G. Bekker, Chioko Nagao, Satomi Niwa et al.· Protein Science· 1 citation
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