Sep 2026
Abstract B012: In vivo Mini screen to assess the Antitumor Effect of Carboxyamidotriazole orotate (CTO) and temozolomide (TMZ) in Monotherapy in Three ITCC-P4’s High-grade Glioma (HGG) Pediatric Patient Derived Xenograft (PDX) Tumor Models
The aim of this study was to evaluate in vivo antitumor activity of CTO, a novel, oral small molecule orotate formulation of carboxyamidotriazole (CAI). The antiproliferative and antimetastatic properties of CTO are driven by the inhibition of calcium influx through receptor-operated channels. By disrupting calci...
R. Karmali, Romina Walter, J. Gojo et al.
· Cancer Research · 0 citations