Author

Georgios Megalovasilis

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Open access Sep 2026

Z-DNA-associated genomic instability in the human pangenome

Abstract Z-DNA is a non-canonical, left-handed nucleic acid conformation implicated in gene regulation and genome instability. Long-read sequencing and telomere-to-telomere genome assemblies now enable analysis of repetitive regions that were absent or incompletely represented in earlier human references. Leveraging T2...

I. Georgakopoulos-Soares, Georgios Megalovasilis, Eleftherios Bochalis et al. · Research Square · 0 citations