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Author

Gerardina Smaldone

2 papers indexed here

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Open access Aug 2026

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Novel mechanistic insights are provided into the molecular mechanisms governing Kv7 channel modulation by exogenous ligands which may prove useful to target Kv7 channels with more potent and selective modulators.

T. Ciaglia, G. Carleo, Zhenni Yang et al. · 0 citations
Open access Jul 2026

Identification of a New, Potent, and Stable Tetrahydroquinoline-Based 5‑LOX/sEH Dual Inhibitor with Polymodal Anti-Inflammatory Activity in Acute Pancreatitis

Findings reveal compound 11 as a promising anti-inflammatory agent supporting dual 5-LOX/sEH inhibition, coupled with Nrf2 activation, as a viable strategy for AP, showing potent in vitro inhibition of both enzymes and satisfactory metabolic stability.

D. D'Avino, T. Ciaglia, P. M. Jordan et al. · 0 citations

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