Open access
Jul 2026
WASP: a pipeline for functional annotation prediction based on AlphaFold structural models
WASP highlights how structural homology can systematically discover annotations missed by sequence-based approaches, predicting protein functions from AlphaFold structures using network-based structural homology and filling metabolic model gaps by mapping 75-100% of orphan reactions.
Giorgia Del Missier, Kiyan Shabestary, Rodrigo Ledesma-Amaro
· Nature Communications · 0 citations